Hepatitis E is a liver disease caused by infection with a virus known as hepatitis E virus (HEV).
Every year, there are an estimated 20 million HEV infections worldwide, leading to an estimated 3.3 million symptomatic cases of hepatitis E1, and 56 600 hepatitis E-related deaths2.
Hepatitis E is usually self-limiting but some cases may develop into fulminant hepatitis (acute liver failure).
The virus is transmitted via the faecal-oral route, principally via contaminated water.
Hepatitis E is found worldwide, but the prevalence is highest in East and South Asia.
A vaccine to prevent hepatitis E virus infection has been developed and is licensed in China, but is not yet available elsewhere.